The latest study found that American scientists: a mechanism for smoking-induced lung cancer

Lung cancer is the world's most common form of cancer, patients diagnosed each year up to 1,300,000. A lot of studies have shown that between smoking and lung cancer are closely linked, but the specific mechanism has not been clarified. American scientists recently discovered that a particular protein content would lead to the reduction of DNA damage, thereby triggering lung cancer. The discovery may help scientists in the future to improve the treatment of lung cancer. Related papers online May 13 published in the "British Journal of Cancer" (British Journal of Cancer) on. 

    

     Leaders of the study are the United States, Oregon Health & Science University (Oregon Health & Science University) Cancer Institute Laura Hays. This particular protein, called FANCD2, it is in the protein family with hereditary Fanconi anemia (Fanconi anemia), and with this person anemia low protein content of the family, more time in the young of cancer. 

    

     Researchers in the lab has created an artificial trachea to the lungs of smokers simulated environment, as studied in tobacco cells the effects of different proteins. The results showed that, when the lung cells when exposed to cigarettes, FANCD2 manufacturing speed will be slowing down, leading to lower its content. And the role of FANCD2 is through DNA damage or promote repair defective cells to commit suicide to prevent cancer, so the low levels of FANCD2 lead to DNA damage, thereby triggering cancer. 

     Hays said, "This discovery shows that FANCD2 in protecting lung cells against cigarette invasion play an important role, but also may explain why cigarettes so harmful to lung cells." 

     Thesis advanced authors, the United States Portland Veterans Affairs Medical Center in Grover Bagby said: "This study shows that FANCD2 is an important cancer resistance protein, which would undermine its cigarette manufacturing process. Although there may also contain other proteins , but we know that FANCD2 is a critical one, because a very high standard FANCD2 contains cells able to resist the poisoning effect of cigarettes. " 

     Institute of Cancer Research UK's Lesley Walker said: "This research increases our understanding of the reasons for smoking lethal understanding. Smoking causes cancer is currently the single biggest preventable causes of 10 cases of lung cancer in 9 cases have been pumping caused by tobacco. But the good news is that the effect of smoking cessation - quit smoking 5 years later, the risk of heart attack will be reduced to half of smokers, 10 years later, the same risk of lung cancer would be halved. "