According to the foundation study found that 13-Cis retinoic acid (RA) and interferon (IFN) for squamous cell carcinoma of the skin cells have to prevent proliferation and promote differentiation, which has immunomodulatory and chemopreventive effects. Therefore, the combined RA whether interferon can prevent skin cancer arising from violations of the second primary tumor (Second primary tumor, SPT), as well as relapse, Texas Anderson Cancer Center on 66 patients with aggressive skin cancer research, in the postoperative or after radiation therapy, a group not given the treatment (ie control group), another group was given the combined treatment of RA (1 mg / kg / d orally) and interferon (3 x 106 U subcutaneously three times per week), continuous given for 6 months.
It is disheartening that such a differentiation therapy and the skin should not reduce the recurrence of squamous cell carcinoma and the prevention of invasive skin cancer arising from the second primary tumor.
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