Young high-grade breast cancer early detection the survival benefit

The "leaves" of a famous singer, "Asan", died yesterday morning due to breast cancer, a 34-year-old year, it is too hush sob, to remind physicians, the study found that young breast cancer some higher grade, easy to relapse, calling young women, do not overlook health check self-censorship and the importance of early diagnosis and treatment of early detection, breast cancer survival rate is quite high. (Xu Yun Xiang reports) 

 According to statistics, the East race, including Taiwan, Singapore, Hong Kong and other countries, the peak age of onset of breast cancer compared with European and American young age, often can be seen clinically young women with breast cancer cases, in addition, some surveys also found that young women think they do not may be young, breast cancer, or more conservative, they neglect to check, resulting in the detection, the breast cancer may have been relatively late. 

 Professor of Surgery at National Taiwan University Hospital, Breast Cancer Prevention Foundation, King-Jen Chang said that the women in addition to self-examination, the importance of regular medical checks, especially in some research found that most of the younger breast cancer patients, if it is negative for hormone receptors, epidermal growth factor is not the performance or over-performance, higher grade, more rapid course of evolution or the metastasis and recurrence, if uncovered as soon as possible, and help enhance the survival rate, "Comparison of a young man, you can check through the breast ultrasound examination, age Great point, after 50 years of age, mammography acceptable, can be found relatively early stage of breast cancer cells can not touch. " 

 King-Jen Chang stressed that if the early treatment of breast cancer, in many cancers is a very good prognosis of cancer, such as clinical, some are teens, more than 20-year-old female breast cancer, because early detection, coupled with treatment, After breast cancer, but also get married and have children, family case successfully called Women Do not overlook the importance of screening by, especially those with a family history of the women, but also to be more vigilant.

Computer knife radiation therapy for cancer

Robot computer can be the treatment of cancer? National Taiwan University Hospital has recently introduced the latest "computer knife" for the treatment of lung, liver and brain and spinal cord tumor and so on, while surgery, radiation therapy side without surgery surgery, no anesthesia, an average of three days can be effectively inhibited tumor cells. 

 "Computer robot arm like a knife!" National Taiwan University Hospital and director of the Center for computer knife ZENG Han-min pointed out that the knife can be computer tracked the location of the tumor patients, 140 tab through to find out to determine the site, and have 12 points each different point of view, resulted in a total of 1680 rays. Therefore, the radiation can focus light, do not harm normal tissues.

Rui-speed knife treatment within 1 mm of error Tatsu

From National Taiwan University Hospital's "spiral knife" Centers in the United States prior to the Chang Gung Memorial Hospital has recently spent nearly billion, the introduction of the "speed sharp knife" radiation therapy instrument. The hospital stressed that the use of the latest radiotherapy equipment, can significantly shorten treatment time, each time for less than two minutes, with the image-guided, so that the treatment of error of up to 1 mm. 

 Taiwan more than 50-year-old Mr. Lin, a few months ago found a right side of his neck grow prominence, biopsy confirmed to be at the end of tongue cancer with right side of his neck lymphoma transfer, required to undergo chemotherapy and radiation therapy, but conventional radiotherapy easily cause severe dry mouth, etc. side effects, so that deter him. Recently, he accepted the "speed sharp knife" radiation therapy, in the precise image-guided, the treatment of error of only 1 mm, doctors operate, they can try to avoid the spinal cord, salivary glands and other vital organs and reduce postoperative side effects such as dry mouth. 

 Linkou Chang Gung Memorial Hospital, director of radiation oncology Ji-Hong Hong pointed out that the hospital has treated eight and a head and neck cancer and prostate cancer patients, the effect has been quite good. In line with image-guided technology, the "sharp knife-speed" can be precisely aimed at cancer, compared with conventional radiotherapy, just one tenth of the dose, we can achieve the same effect, and significantly reduce treatment time, the average treatment time Just two minutes.

Lung cancer screening will help the families of early detection

Smoke, have a family history of lung cancer were the two major high-risk groups, such as the Chang Gung Memorial Hospital research team for lung cancer families to low-dose 64-section computed tomography (64-cut CT) examination showed 15% abnormal ratio, a high degree of suspicion reached 6.5% in the proportion of lung cancer, one of lung cancer has been confirmed. 

 Lung cancer in 10, not only among the best, the death toll rose year by year, Chang Gung Memorial Hospital, Ying-Huang Tsai, vice president, said the effect of early treatment of lung cancer better, but found that difficult, Chang Gung Memorial Hospital statistics into more than five cases at the time of diagnosis is late. 

 Ying-Huang Tsai said, smoking and lung cancer has a high degree of correlation is an indisputable fact that, while family history of lung cancer is also a risk factor that can not be ignored. Internal research shows that parents or brothers and sisters have one person suffering from lung cancer, lung cancer is its 2-fold higher than the opportunity, if the pro-3, etc. have been more than two or more lung cancer, which is the so-called "multi-family", their lung cancer machine rate was even higher than 14-fold. 

 Past studies have shown the traditional X-ray is very difficult to find early lung cancer, in recent years, many to make computer tomography examination, according to foreign large-scale studies have shown that for most people to carry out a CT scan, a lung cancer screening were a total of about 0.3% to 0.5%, while for smoke screening high-risk group, while there is 2-3% of patients with lung cancer, Ying-Huang Tsai note, this shows that for high-risk groups for screening the effectiveness of good, but also more effective. 

 Since last October, Chang Gung Memorial Hospital and Medical Center 6 studies, the use of CT screening for all 64 family members of patients with lung cancer nearly 300 people and found that 15% of people have lung nodules 0.5 cm or more, one of more than 1 cm, then a high degree of suspicion 6.5% for lung cancer, smokers are twice as many lung cancer groups, but also find many hair from family 3 family members suffering from lung cancer. 

 Ying-Huang Tsai note, preliminary studies have shown that for high-risk groups for CT screening helps early detection of lung cancer, lung cancer patients in Taiwan have 8 into a female, not male smokers into 3 groups, so he suggested that smoking as well as those who can have a family history of early screening, early detection of lesions, treatment, does not encourage everyone to screening, and healthy lifestyles are still far away from cancer prevention.

American opera queen seats Mills died of lung cancer at the age of 78

U.S. media reports, in 1971 by Time magazine called "American opera queen," the famous coloratura Beverly Mills ‧ seat, died today of lung cancer at the age of 78 years old. 

 I Mills Ukraine and Romania are the descendants of Jewish immigrants, was born in New York, from 1,950 to 70 years, to tone with the simple appeal of the charming world. 

 Mills I often because television talk show, dark by the mainstream audience favorite, she approachable manner and dynamic television charm, so she became the chief American heroine in mind, even if it is never to go to the theater audience She likes the same. 

 Her story on behalf of poor origin, after years of struggle, family tragedy, artistic achievements of the typical American success story, American opera singer in that generally go abroad for training and to seek job opportunities in years, I Mills are a product of the United States, and even In the 36-year-old, she had never performed in Europe. 

 Opera singer who at the time fixed in the "Johnny Carson Tonight Show" program, and I was the only Mills was invited to host on behalf of classes of the opera star, also with, Danny Kaye, such as harmonic Star cooperation. 

 Years of excellence in concert career, I have charge of the Metropolitan Opera Mills, New York City Opera and Lincoln Center, wearing management talent prior to retirement in 1980, a total of eighteen sets of the whole recording of this opera. 

 I Mills family announced her lung cancer last month in bed seriously ill. 

 The New York Times today quoted seats Vincent Mills brokers reported that Mills seats are unable to cut the death of lung cancer. 

 Mills I press her husband's death in September 2006 was.

Well-known American country music singer Merle Haggard accepted • lung cancer surgery

Xinhua Beijing November 10 well-known American electric country music singer-composer Gede said a spokesman for 9 day, 71-year-old Haggard had been diagnosed with lung cancer, and on the 3rd of this month in Bakersfield, California Rumsfeld at a hospital surgery is currently recuperating at home. 

     Reuters quoted a statement Haggard said: "I feel good ... ... to improve. If it is not my wife (Teresa) of love and wisdom, I may not be up to today." 

     The statement said that the biopsy results showed that Haggard with non-small cell lung cancer, doctors removed the right lung upper lobe Haggard. Examinations showed that all illness has been removed. 

     According to American Lung Association said that the lung cancer the most common type of non-small cell lung cancer, with relatively less common compared to small cell lung cancer, non-small cell lung cancer spread to different parts of the body more slowly, and easier surgical resection and chemical therapy. 

     The association said that the lung cancer patients are men and women of the United States number one killer. Patients with lung cancer 5-year survival rate of 16%. 

     Haggard 60s are the 20th century the most important people of country music, country music are the United States and the representative of an evergreen tree, obtained by the size of country music awards numerous, with dozens of the first singles champion. His creative blend of folk songs, jazz, pop and blues music and many other characteristics.

Urine testing can be uncovered malignant prostate cancer

University of Michigan researchers found that urine samples through the inspection, can be uncovered malignant, highly aggressive prostate cancer, looking forward to let the disease is not so serious in patients with prostate cancer suffer less points. The study is published in "Nature" (Nature) journals. 

 In Taiwan, men accounted for malignant prostate cancer ranking fifth in the urinary tract malignancies, the first prostate cancer are on. Prostate cancer patients, some patients with particular ferocity, tumor grade is also relatively high. The medical community has been hoping to find a method of early identification. 

 Some prostate tumors grow slowly, and patients often end up not die of cancer, but death due to other diseases. But some prostate tumors are also fierce and fast growing, these patients need treatment immediately. But the medical staff it is difficult to differentiate the difference between two types of tumors, so let some prostate cancer patients unnecessary surgery or chemotherapy treatment, patients often suffer. 

 The researchers found that, when the physical face of aggressive prostate cancer, the body will produce a small molecule called the "glue acid methyl Gan" (Sarcosine), the future of plastic acid methyl Gambari may be able to become a tumor marker, to allow medical staff more accurately grasp the condition. However, the U.S. admitted the University of Michigan researchers, the study is still an early stage, if there is a clear outcome to wait at least 5 years. 

 Researchers at the pathological examination of 262 samples, these samples are from organizations, blood or urine samples containing 1126 kinds of molecules. The researchers point out that when patients with a more malignant form of cancer, the samples can be found about 10 kinds of molecules, metabolites. One metabolite is plastic acid methyl Gan. Researchers have discovered that malignant tumors, cancer proliferation in patients with urine, tissue glue acid methyl Gambari has increased the trend. The study pointed out that plastic acid methyl Gambari may help cancer proliferation, the future of R & D of new drugs when the gel acid methyl Gambari might be classified as a potential therapeutic target.

Simulation of DNA damage to cancer cells to commit suicide

Xinhua News Agency this morning on the 15th the French researchers published studies indicate that people can use a molecular "bait" to simulate the DNA damage, thereby promoting cancer cells to commit suicide. 

 Marie Curie Institute in Paris, France Teles led the researchers to produce small DNA fragments, copying the genetic code at both ends of the double helix structure of damaged, so that those stubborn cancer cells think they are seriously damaged, and "suicide", that is, programmed cell death. 

 The research results were published in the latest issue of the United States, "Clinical Cancer Research" on. The researchers said that a number of malignant tumors are resistant to conventional therapy, this study has opened up a new deal with malignant road. 

 In mice to do the experiments showed that rats with radiation therapy before the use of this method, the elimination of 75% to 100% of the cancer cells, but only with radiation therapy, only the destruction of 30% to 50% of cancer cells. 

He said that if all goes well, researchers may be the beginning of the end of 2010 volunteers started in clinical trials.

Act scientists find "bait" to lure cancer cells "commit suicide"

According to Xinhua News Agency, the French electricity researchers announced on the 15th study shows that people can use a molecular "bait" to simulate the DNA (DNA) damage, thereby promoting cancer cells to commit suicide. 

 Doctors often use chemotherapy and radiation therapy damage to cancer cells, thereby causing programmed cell death. However, for some time, these therapies to the cancer cells enough to damage caused by programmed cell death provoked, and who survived cancer to self-repair, so that the course of treatment to no avail. 

 To deal with this situation, Paris, France, Marie Curie Research Institute Teles led researchers to create small DNA fragments, copying the genetic code at both ends of the double helix structure of damaged, so that those stubborn cancer cells that they suffer serious , thereby "committing suicide", that is, programmed cell death. If all goes well, researchers may be the beginning of the end of 2010 volunteers started in clinical trials.

Check the Kras gene has become the treatment of colorectal cancer approach

Due to advances in molecular biology, found that some liver gene mutation or DNA changes happen many types of drugs can cause different reactions and side effects of the increase or reduction, such as lung epithelial growth factor receptor (EGFR) mutations were generated to target drugs such as Iressa or Tarceva have relatively good efficacy, but the wild-type (EGFR wild type) although there is no effect of mutant, but still has a certain effect, so for the wild-type group also they should not refuse treatment. But since 2006 found that the availability of colorectal cancer in patients with mutations in Kras target for drug treatment is effective, has a very clinical phase of clearance. 

In the EGFR inhibitor cetuximab or Medium panitimumab, KRAS mutation and treatment efficacy have not greatly affected. In other words, when EGFR mutations have used the two target drugs are not curative, that is, whether the combined chemotherapy of their clinical efficacy of cetuximab did not make much difference. Therefore, in the United States and Taiwan also began to study the use of EGFR inhibitors, colorectal cancer is best to first check whether Kras gene mutation, if mutation has suggested that non-use of cetuximab. Kras mutation that accounts for nearly 30 ~ 40% as much as, if prior inspection Kras gene mutations in patients who have no need to use the target treatment can not only reduce the occurrence of side effects can also reduce unnecessary costs, because the cost of expensive drug target , for the people, society and country are a great burden.

For liver metastasis of colorectal cancer patients can not use chemoembolization may extend survival

Colorectal cancer liver are most likely to transfer the place, once the transfer, by chemical treatment such as FOLFOX part of the formula may have the patient can be reduced and surgery and chemotherapy failed surgery should not have some of the patients can use such as radiofrequency tumor ablation methods, can also be used Y90 chemoembolization or embolization, such as radiology. Recently, University Hospital Frankfurt, Germany Wolfgang physician's report, he would colorectal cancer unresectable liver metastasis failed to respond to chemotherapy and 463 patients, average age is 62.5 years old, 67.4% of patients have liver metastasis 5 points, 8% only a transfer point, 14.3% are 3-4 shift points, 10.4 percent have two transfer points. Every four weeks with chemoembolization method, with an average 5.3 times for each person, the use of drugs, including lipiodol, starch microspheres for vascular occlusion at the same time together with mitomycin C, gemcitabine or irinotecan. 463 patients 14.7% of patients have some of remission, 48.2% of patients with stable, 37.1% of patients deteriorated, one-year survival are 62% two years survival was 28%, from the beginning has an average survival of liver metastasis period is 38 months for the embolization was 14 months. With mitomycin C, gemcitabine, or irinotecan survival are the same. No statistical difference, so think Wolfgang chemoembolization for liver metastasis of colorectal cancer patients is not a very good treatment.

The United States Food and Drug Administration approval of Gleevec in Gastrointestinal Stromal Tumor

Intestinal stromal tumors (GIST) is a relatively rare sarcoma, mainly from the deterioration of Cajal cells and long out of mass, previous surgery apart from early detection, there is no better method of treatment. But even surgery, it is still very high relapse rate. Later, American researchers found basic molecular biology of gastrointestinal stromal tumor cell surface of the Kit gene will be abnormal, and abnormal Gleevec itself Kit cancer have curative effects, so the United States Food and Drug Administration approved Gleevec in metastatic or recurrent gastrointestinal stromal tumor patients. As a result of post-surgical gastrointestinal stromal tumor patients, because even if curative surgery, it is still very high relapse rate. Thus the recent gastrointestinal stromal tumors after surgery whether or not Gleevec study also found that patients given Gleevec one year after the relapse rate is lower than the control group, so Gleevec can be used as adjuvant therapy to reduce post-surgical gastrointestinal stromal tumors recurrence.

Treatment of Colorectal Cancer News

Just last year, held in June of Clinical Oncology American Medical Association Council meeting in a discussion like the treatment of colorectal cancer event, from the stages of disease, early colorectal cancer postoperative adjuvant chemotherapy treatment of metastatic colorectal cancer treatment have a wonderful report and the results of these studies may change our future for colorectal cancer treatment modalities. 
Because the United States for chemotherapy of colorectal cancer varies with Taiwan, this article only introduce several important results and personal opinion. At present, commonly used in colorectal cancer drugs, including 5-FU, Leucovorin (LV), Irinotican and oxaliplatin four, at this meeting in a well-known French scholar deGramont report of a response to the second and third period in patients with colorectal cancer postoperative adjuvant chemotherapy of clinical trial (MOSAIC trial) results and found that the oxaliplatin plus 5-FU and LV alone than 5-FU and LV is better, if the results of the United States for another large-scale clinical NSABP C07 trial confirmed, perhaps the future should be the use of oxaliplatin in colorectal cancer postoperative adjuvant chemotherapy. 

Another study (N9741) is more 5-FU + LV + Oxaliplatin (FOLFOX4), 5-FU + LV + Irinotican (IFL), and Irinotican + Oxaliplatin (IROX) three methods of treatment of metastatic colorectal cancer of the efficacy and Living quality, results showed that FOLFOX4 best, and the IFL and IROX in a par between the three aspects of quality of life almost. FOLFOX4 treatment showed N9741 remission rate of up to 40%, while the IFL and IROX 30%, with a median survival of 19.1 months, respectively, three, 14.8 months and 17.0 months. The results showed that FOLFOX4 in metastatic colorectal cancer in first-line treatment is a good choice. However, the study of this group in the IFL used 5-FU + LV injection and more commonly used in Taiwan is different if its conversion to injection of FOLFOX4 or FOLFOX6 injection (which can be referred to as FOLFIRI) may be different results. 

Another clinical trial (EFC4584) confirmed that patients in the IFL after treatment failure, FOLFOX4 than the separate use of oxaliplatin or 5-FU + LV effects better, FOLFOX4 may improve remission rates and improve symptoms, but it was not clear The median survival period of patients was not significantly prolonged. However, due to the FOLFOX4 very obvious improvement in symptoms, it should recommend the use of FOLFOX4. 

In this meeting with two other monoclonal antibodies used in chemotherapy also have a good score, the first study was aimed to Irinotican treatment failure of patients to give monoclonal antibody C225 or C225 plus Irinotican to continue treatment, results showed that its mitigation rates were up to 10% and 22%, but the latter side effect was high. C225 role in epithelial cell growth factor's receptor, which in the treatment of colorectal cancer should be further exploration of the role will be C225 with FOLFOX or FOLFIRI combination is probably the next step to conduct clinical trials. The second study compared this meeting the most noteworthy of a study, the combined use of a blocking angiogenesis monoclonal antibody Bevacizumab (trade name Avastin) and the IFL than IFL alone to treat metastatic colorectal cancer patients, remission rate can be increased to 35 percent from 45 percent, while the median survival time of 15.6 months may be extended to 20.3 months. The use of Avastin patients more prone to high blood pressure, but the available drugs control, the study is the Buddha Cookman (Folkman) physicians in the 1970s initiated blocking tumor blood vessels can starve to death the first time the theory been tested clinically, but the last one study of Avastin for breast cancer have not shown such efficacy, but also with Avastin + IFL and FOLFOX effects will not be more than better, therefore, clinical use of Avastin might have to wait another several large clinical trials, the results can be confirmed.

Interaction with the children help children reduce the risk of leukemia

U.S. researchers said today that children at nursery school or participating in pre-game ban can reduce the suffering from leukemia (blood cancer) into the risk of the three. 

 

 University of California, Berkeley scholars research team led by Dr.Bafler to view the 14 studies, involving 6108 children with leukemia, as well as 13,704 non-sick children, and to provide the above findings. 

 Ms.Bafler visit the British Broadcasting Corporation said: "The overall view, we found to have engaged in pre-game ban children have the opportunity to young children will have to get along with other children of the social experience, as compared to those who do not have such experience children, they reduce the risk of suffering from leukemia into three. " 

 She said: "This allows us to infection or immune regulation in this process may play a role, a more firm understanding of." 

 The study report for the first time today in London meetings leukemia patients. 

 Childhood leukemia in the industrialized countries, young people very common form of cancer, each one of those 2000 people were infected, scientists believe, there are two "boot device" will lead to childhood leukemia. 

 It is believed that the first reason is that during pregnancy the gene mutation. The second is the cause of the infection period in early childhood led to "inappropriate response", resulting in children are more vulnerable to suffering from leukemia. 

 However, it is believed that through the coughing, runny nose, and other games in the pre-school classes and nursery school children between the spread of disease and "start" the immune system, you can turn off the inappropriate reaction of the second trigger mechanism. 

Bafler said that at present can not thoroughly understand the development of childhood leukemia the exact mechanism, but her research team examined the study, none of the study found that social contact would increase the risk of leukemia children. 

 She said: "We believe that early childhood experience with such children, than those who were left unattended, children, or those who do not have many brothers and sisters or to participate in the experience of the game ban children, but also allows the immune system better prepared to do a good job. " 

 British charity organization "Leukemia Research Foundation," After ten years research, in 2005 also in the "British Medical Journal" published a similar study found.

Elder sister, donated myeloid leukemia rescued 19-year-old female patient

"I have blood in your" feel fantastic! "Chen San-ci 19-year-old when myeloid leukemia (commonly known as cancer of the blood) disease, elder sister, Chen Yi-ling gave transplant pain, to save a life sister, and elder sister, was flowing the same blood, she volunteers at the hospital any return to the love of elder sister, transmitted to other patients with leukemia. 

 Memories of 8 years ago, the incidence process, Chen San-chee said the market seemed to have done a nightmare, when they developed symptoms of fever, headache and other flu-like symptoms, that there is no medication Well, did not expect sustained symptoms until the body is really hard for me to Taoyuan City 1 medium-sized hospital emergency room, and examination of finished blood, doctors found her white blood cell count in excess of the normal four times, dying out notice, and then transferred to larger hospitals. 

 Chen San-chee radiotherapy and chemotherapy after six, but the blood of cancer cells exist, Hematologists Dr. Zhi suggested a bone marrow transplant, three pairs of genes elder, the elder sister, Ling Yi closest; "immediate family members, female transplant to women, the success rate of more than 80%, a little flesh pain, no big deal, "says Chen Yi-ling it easier to comfort her sister, tube into the right thigh, she has more than 10 days lame. 

 "My elder sister, this life is to help me retrieve the past, no, she donated bone marrow stem cells, there is no now, I see her endure the pain caused by surgery, but it is so calm, more pain in my heart." Chen San-chee back recuperating at home after his father's order, the whole family Story difficult for her to create the living environment of the virus isolated in the gate of hell before I go back, she won rebirth, but also cherish the love of family, work in Singapore for a major gratitude for his sister in particular in mind. 

 "The youngest daughter of anti-leukemia large operations, will be a close link to the hearts of people, thanks to master, and finally everything is complete." Devout Christian Chen mountaineering training every day with her daughter, time on the domestic and foreign tourism, family treasure more a "living in the present "; the year before retirement, he was touched by caring little daughter, daughter-kai donation in hand, is a happy father and daughter volunteer file.