Epothilon is an extremely novel mechanism of chemotherapy drugs, half of its volume and inhibitor cytotoxicity with paclitaxel similar, but the expression of P-glycoprotein multidrug resistance cell line cytotoxicity much larger than Taxol, That is to say of the cancer cells are resistant to Taxol still valid.
Taxol is currently due to its unique role in the mechanism to make following cyclophosphamide, Little Red mycophenolate, cisplatin after another important anti-cancer drugs. Epothilones category and ixabepilone, patupilone, BMS-310705, KOS-862 and ZK-EPO are now imported clinical trials. At present, the side effects found for neurotoxicity, as well as lower white blood cell. Which neurotoxicity caused by ixabepilone should be given time with the relevant order.
At present, the application of a single agent for advanced breast cancer, lung cancer, head and neck cancer, esophageal cancer, prostate cancer have a good effect. For the paclitaxel-resistant breast cancer, the effect of the current looks relatively no resistance were slightly worse.
However, resistance to hormone therapy of prostate cancer, Taxol-resistant ovarian cancer is, its effect on the very exciting. ..
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