5 pathogenic factors of malignant lymphoma

Malignant lymphoma, immune cells in the tumor, lymph nodes and extranodal sites lymphoid tissues derived from lymphocytes or malignant tissue. Of malignant lymphoma is relatively rare, but in recent years, new cases increased year by year, at least over 25 thousand cases per year, while in Europe, the Americas and Australia and other Western countries, the incidence may be as high as 11/10 to 18/100 000, slightly higher than the sum of the various types of leukemia.

Malignant lymphoma risk factor:

(1) physical cause (radiation)

The incidence of lymphoma is not only related with the absorption of the radiation dose with age affected by radiation, radiation population under 25 years of age, the incidence of lymphoma than other populations. Medical radiation on the pathogenesis of human tumors affect more and more attention, especially in the high-dose radiation role in promoting human lymphoma.

(2) chemical etiology

Types of chemical carcinogens, alkylating agents, polycyclic aromatic hydrocarbon compounds, aromatic amines, and the incidence of malignant lymphoma certain. The chemical drugs caused the occurrence of malignant lymphoma is not rare, such as cyclophosphamide, procarbazine, melphalan caused malignant lymphoma have been reported. Malignant lymphoma of the rural population in agricultural production, with the application of pesticides and fertilizers, morbidity and mortality rates continue to increase.

(3) immune factors

The malignant lymphoma malignancies of the immune system, immune deficiency is an important cause of malignant lymphoma. Under normal circumstances, the body's immune system has the functions of immune surveillance, mutated or cancerous cells in vivo can play the role of removals. Immunocompromised patients susceptible to opportunistic infections, especially viral infections.

(4) genetic factors

Genetic factors associated with the etiology of malignant lymphoma reported in many aspects, sometimes seen significant familial aggregation, such as brothers and sisters can be successively or simultaneously suffering from malignant lymphoma.

(5) viral etiology

The virus is an important direction of research in cancer etiology. Current research situation in close relationship with malignant lymphoma virus EB virus, human T-lymphotropic virus viral human tropism B lymphocytes.